PIN17 Pharmacoeconomic Analysis of Antiretroviral Therapy (ART) Based on Local D?ta from Real Clinical Practice, and Modeling Changes in Approaches to the HIV Treatment in the Russian Federation

The aim of the work was to economically evaluate existing ART practice and model consequences new recommendations in HIV treatment with expansion genotyping dolutegravir use based on developed local epidemiological data model. methodology included two stages: statistical processing from patient database (1,113 patients receiving ART, Center for AIDS Prevention Control records 2011-2016), development a mathematical model, that allows economic aspects various therapeutic approaches implementation. Modeling following scenarios: #1: Implementation recommendations; #2: Genotyping at 1st scheme without changing ART; #3: - resistance level 5.3%; #4: 50% cases. Model input parameters: distribution accordance simulated scenarios, cost routine genotyping. During estimated period, 80% prescribed regimens less than 37,000 rubles. Each subsequent regimen 5-10% more expensive previous one. had 2 13 changes. volume regardless therapy stage did not exceed 10%. most commonly ARTs were zidovudine, lamivudine, efavirenz, nevirapine, ritonavir-lopinavir. costs considered amounted 848,979,644 When simulating planned there tendency slightly reduce or increase (within 10%). introduction personalized approach selection managing HIV-infected due decrease number increased first line increases up